Molecular screens for inner ear genes
نویسندگان
چکیده
منابع مشابه
Molecular mechanisms of inner ear development.
The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Henc...
متن کاملThe molecular architecture of the inner ear.
The inner ear is structurally complex. A molecular description of its architecture is now emerging from the use of contemporary methods of cell and molecular biology, and from studies of ontogenetic development. With the application of clinical and molecular genetics, it has now become possible to identify genes associated with inherited, non-syndromic deafness and balance dysfunction in humans...
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Recent developments in medicine have given us a better insight into a group of disorders known as autoimmune diseases. In particular, advances have occurred in our understanding of the Autoimmune Inner Ear Disease (AIED). In this article, the authors review the different postulated theories in the pathogenesis of this disease. The clinical presentation, the available para-clinical diagnostic to...
متن کامل09-P050 SoxE genes in mouse inner ear development
ware employs image filtering and mathematical morphology techniques. It counts cell number from a confocal stack of images, by analysing cells in 2D and 3D throughout the whole stack. Quantification is automatic, accurate, objective and very fast, enabling reliable comparisons of multiple specimens of diverse genotypes. Although DeadEasy was developed and validated for Drosophila, it can be use...
متن کاملMolecular architecture underlying fluid absorption by the developing inner ear
Mutations of SLC26A4 are a common cause of hearing loss associated with enlargement of the endolymphatic sac (EES). Slc26a4 expression in the developing mouse endolymphatic sac is required for acquisition of normal inner ear structure and function. Here, we show that the mouse endolymphatic sac absorbs fluid in an SLC26A4-dependent fashion. Fluid absorption was sensitive to ouabain and gadolini...
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ژورنال
عنوان ژورنال: Journal of Neurobiology
سال: 2002
ISSN: 0022-3034,1097-4695
DOI: 10.1002/neu.10122